for Dogs (cyclosporine oral solution) USP MODIFIED 100mg/mL 30mL

MODULIS for Dogs (cyclosporine oral solution) is a systemic immunosuppressant that may increase the susceptibility to infection and the development of neoplasia. MODULIS for Dogs is contraindicated for use in dogs with a history of neoplasia. Do not use in dogs with a hypersensitivity to cyclosporine. The 1 mL syringe is graduated in 1 lb increments corresponding to 0.023 mL/lb. This syringe is for dosing dogs 4 to 40 lb. The 1 mL syringe will be included with the 15, and 30 mL bottles. The 3 mL syringe is graduated in 5 lb increments corresponding to 0.115 mL/5 lb. This syringe is for dosing dogs 41 to 125 lb. The 3 mL syringe will be included with the 30 and 50 mL bottles.

MODULIS for Dogs is indicated for the control of atopic dermatitis in dogs weighing at least 4 lbs. (1.8 kg) body weight. Often used extra-label for perianal fistulas (anal furunculosis), immune-mediated blood disorders (eg, immune-mediated hemolytic anemia [IMHA]), inflammatory bowel disease, idiopathic chronic hepatitis, sebaceous adenitis, sterile nodular panniculitis, and the treatment of various immune-mediated disorders in dogs.

Gastrointestinal problems and gingival hyperplasia may occur at the initial recommended dose. The most commonly reported adverse reaction was vomiting. Dogs often vomit when starting therapy, but this generally abates with time. Other observed adverse reactions included diarrhea, persistent otitis externa, urinary tract infections, anorexia, lethargy, and lymphadenpathy. Talk to your veterinarian if your dog experiences any changes in behavior or other adverse effects.

The safety and effectiveness of cyclosporine has not been established in dogs less than 6 months of age or less than 4lbs body weight. MODULIS for Dogs is not for use in breeding dogs, pregnant or lactating bitches. As with any immunomodulation regimen, exacerbation of sub-clinical neoplastic and infectious conditions may occur. MODULIS for Dogs may cause elevated levels of serum glucose and should be used with caution in cases with diabetes mellitus. If signs of diabetes mellitus develop following the use of MODULIS for Dogs, consideration should be given to tapering or discontinuing the dose. MODULIS for Dogs should be used with caution in dogs with renal insufficiency. Killed vaccines are recommended for dogs receiving MODULIS for Dogs because the Killed vaccines are recommended for dogs receiving MODULIS for Dogs because the impact of cyclosporine on the immune response to modified live vaccines is unknown.